Dr. S. Sivakumar
Associate Professor, Department of Biochemistry, Sri Sankara Arts and Science College (Autonomous),
Enathur, Kanchipuram, India
Ttle of presentation: Identification of active principle from the leaf extracts of MeliaAzedarachL., Andrographis Paniculataand Azadirachtaindica through bioinformatics tools
Medicinal plants are nature’s gift to human beings for leading healthy life. Bioinformatics is the convergent field of biology and computer science. Researchers in scientific disciplines are finding difficulty to identify the active principle of medicinal plants which are the need of the hour for the development of side effect free chemotherapy. In the present study, biochemical and bioinformatics tools were utilized to identify the active principle in the leaf extracts of MeliaAzedarach L., AndrographisPaniculataandAzadirachtaindica. The GC-MS analysis of leaf extracts of MeliaAzedarach L., AndrographisPaniculataandAzadirachtaindica reported eleven novel natural compounds. The chemical structures of these eleven compounds were retrieved from PubChem database. With the help of molecular docking studies along with known drugs and disease targets, one active principle was identified. The final result was also supported by the molinpiration tool and Lipinski’s rule of five. The identified active principle is 3-Cyclohexen-4-ol-1-one, 3-tridecanoyl from Andrographispaniculata.
Keywords: Medicinal plants, GC-MS, Drug designing
Dr. S. Sivakumar was awarded Ph.D. in Biochemistry from University of Madras. He had cleared National Eligibility Test (NET) and Junior Research Fellowship exams conducted by UGC-CSIR and ICMR. He had also eligible for Junior Research Fellowship provided by ICAR. During his academic he received Best Performer award in 2016 and Best Teacher Award for excellence in teaching. He had published eight books in the field of science. He had also deposited twenty entries in Bioinformatics databases like genbank and genpept. He is also a member (Tamil Nadu State Council of Educational Research and Training) and subject expert for Biochemistry.